Team 4 / Theme 3

Team 4 / Theme 32018-03-30T20:32:54+00:00

Dysfunction of the smooth muscle plasticity in digestive Drapeau Françaispathologies

Alterations in the molecular mechanisms that control the development of the digestive musculature could be present in specific digestive disorders. Interestingly, we really found that abnormal high RBPMS2 expression levels are present in paediatric patients who suffer from such CIPO (Chronic Intestinal Psesudo Obstruction, see the website: https://www.association-poic.fr) but also in adult GIST patients (Notarnicola et al., Gastroenéquipe 4 thème 3terology 2012;  Hapkova et al, Ex Mol Pathol 2013).

Therefore, the main objectives of the third theme are to identify and elucidate the molecular mechanisms that participated to the alteration of the digestive smooth muscles in chronic diseases (e.g. CIPO, GISTs and diabetes) in order to develop effective therapeutic strategies and/or diagnostics to reduce muscle dysfunction (read more).

 


 Collaborations :

  • G. Labesse, et J.F. Guichou (CBS, CNRS/INSERM, Montpellier),
  • JM. Vanderwinden (Université Libre Bruxelles, Belgium),
  • S. Thorsteinsdottir (University of Lisbon, Portugal),
  • G. Andelfinger (CHU St Justine, Montreal, Canada),
  • F. Joly (Pôle des maladies de l’appareil digestif, Hôpital Beaujon, Paris),
  • F. Chibon (Institut Bergomié, INSERM, Bordeaux),
  • M. Plateroti (Centre de Génétique et de Physiologie Moléculaire et Cellulaire, CNRS, Villeurbanne),
  • JN. Freund (INSERM U1113, Strasbourg).

Financial supports :

  •  AFM
  • ARC
  • Association des POIC

Coordinator :

De Santa Barbara Pascal

 Participants :


Major Publications :

Collaboratives Publications :

Patents :

  • De Santa Barbara, P. and Guichou, JF. (2014) « Methods and Pharmaceutical compositions for treatment of Chronic Intestinal PseudoObstruction: CIPO/RBPMS2. » International Patent WO2014122199-A1.
  • De Santa Barbara, P. and Guichou, JF. (2014) « Methods and Pharmaceutical compositions for treatment of Gastrointestinal Stromal Tumors: GISTs/RBPMS2. » International Patent WO2014057045-A1.
  • Montero, JL., Montero, V., Molès, JP., de Santa Barbara, P., Clavel, C. and Jover, B. (2011) « Use of D-mannopyranose derivatives as anti-cancer activity. » International Patent. WO2011058245-A1.
  • Montero, JL., Montero, V., Molès, JP., de Santa Barbara, P., Clavel, C. and Jover, B. (2009) « Use of D-mannopyranose derivatives as activators of angiogenesis. » International Patent WO2009138600-A3.
  • Montero, JL., Montero, V., Molès, JP., de Santa Barbara, P., Clavel, C. and Jover, B. (2009) « Use of D-mannopyranose derivatives as inhibitors of angiogenesis. » International Patent WO2009138601-A3.