Dysfunction of the smooth muscle plasticity in digestive Drapeau Françaispathologies

Alterations in the molecular mechanisms that control the development of the digestive musculature could be present in specific digestive disorders. Interestingly, we really found that abnormal high RBPMS2 expression levels are present in paediatric patients who suffer from such CIPO (Chronic Intestinal Psesudo Obstruction, see the website: https://www.association-poic.fr) but also in adult GIST patients (Notarnicola et al., Gastroenéquipe 4 thème 3terology 2012;  Hapkova et al, Ex Mol Pathol 2013).

Therefore, the main objectives of the third theme are to identify and elucidate the molecular mechanisms that participated to the alteration of the digestive smooth muscles in chronic diseases (e.g. CIPO, GISTs and diabetes) in order to develop effective therapeutic strategies and/or diagnostics to reduce muscle dysfunction (read more).


 Collaborations :

  • G. Labesse, et J.F. Guichou (CBS, CNRS/INSERM, Montpellier),
  • JM. Vanderwinden (Université Libre Bruxelles, Belgium),
  • S. Thorsteinsdottir (University of Lisbon, Portugal),
  • G. Andelfinger (CHU St Justine, Montreal, Canada),
  • F. Joly (Pôle des maladies de l’appareil digestif, Hôpital Beaujon, Paris),
  • F. Chibon (Institut Bergomié, INSERM, Bordeaux),
  • M. Plateroti (Centre de Génétique et de Physiologie Moléculaire et Cellulaire, CNRS, Villeurbanne),
  • JN. Freund (INSERM U1113, Strasbourg).

Financial supports :

  •  AFM
  • ARC
  • Association des POIC

Coordinator :

De Santa Barbara Pascal

 Participants :