The overall objective of the unit is to identify the molecular mechanisms involved in heart and muscle functions but also to use the synergy between basic and clinical research to better understand the physiopathological mechanisms involved in cardiovascular diseases :
heart failure, acquired and inherited arrhythmias, congenital cardiopathies,
acquired muscle defects as chronic obstructive pulmonary disease (COPD),
obesity and type 2 diabetes (T2D), and chronic kidney disease (CKD)
inherited muscle pathologies such as muscular dystrophies such as Duchenne muscular dystrophy (DMD), or facioscapulohumeral dystrophy (FSHD), and iatrogenic muscle defects (myopathy induced by mechanical ventilation or local anesthetics).
Within the unit, we have a unique combination skills and equipment needed to investigate heart and muscle functions in animal models as well as at the cellular and molecular levels in human/animal tissues and cells. The driving force of the new unit is translational research.