The overall objective of the unit is to identify the molecular mechanisms involved in heart and muscle functions but also to use the synergy between basic and clinical research to better understand the physiopathological mechanisms involved in cardiovascular diseases :

heart failure, acquired and inherited arrhythmias, congenital cardiopathies,

acquired muscle defects as chronic obstructive pulmonary disease (COPD),

obesity and type 2 diabetes (T2D), and chronic kidney disease (CKD)

inherited muscle pathologies such as muscular dystrophies such as Duchenne muscular dystrophy (DMD), or  facioscapulohumeral dystrophy (FSHD), and iatrogenic muscle defects (myopathy induced by mechanical ventilation or local anesthetics).

Within the unit, we have a unique combination skills and equipment needed to investigate heart and muscle functions in animal models as well as at the cellular and molecular levels in human/animal tissues and cells. The driving force of the new unit is translational research.

Research

** 4 main areas of Research are developed within the INSERM unit U1046 entitled : « Physiology & Experimental Medicine Heart and Muscles »:

Team 1 – Ion channels and calcium homeostasis in cardiac muscle and vascular muscles.

Our research focuses on the identification of novel cellular and molecular mechanisms of cardiac and vascular pathophysiology in order to offer new therapeutic options. We recognized in vivo electrophysiology cell expertise, pharmacology, imaging, study of cellular functions (signaling, contractility, proliferation, apoptosis). Applied to experimental models and tissues obtained from patients, it is part of a dynamic development of translational research.

Team 2 – Calcium signaling and function of the sarcomere in cardiac and skeletal muscle.

The research team, basic and clinical, is interested in the analysis of signal transduction leading to the contraction of skeletal muscles during conditions such as myocardial ischemia, ventilatory dysfunction and muscular dystrophies.

Team 3 – Skeletal muscle dysfunction in acquired and inherited diseases.

This team is developing a translational research whose goal is to understand the involvement of skeletal muscle in the pathophysiology of acquired and inherited chronic disease for the development of innovative therapeutic strategies.

 Team 4 – Development of visceral smooth muscle and associated pathologies. 

The main purpose of this research is the identification and understanding of the molecular mechanisms that affect smooth muscles in the digestive chronic diseases (such as motility disorders, disorders of GIST and disorders associated with diabetes).