Team 4 / Theme 2

Team 4 / Theme 22018-03-30T20:25:08+00:00

Digestive mesenchymal progenitor differentiation and mitochondrial dynamicsDrapeau Français

We previously demonstrated that differentiation of digestive mesenchymal progenitors into smooth muscle cells is under the control of signaling pathways such as NOTCH, WNT et YAP/TAZ (Faure et al. Development, 2015 ; McKey et al. BMC Biol, 2016).Interestingly, growing evidences indicate crosstalks between mitochondria and those signalling cascades.

Indeed, it has been show that YAP/TAZ controls the levels of proteins involved in the mitochondrial fusion/fission process (Nagaraj et al. 2012; Deng et al. 2016). Mitochondria are dynamic organelles that continuously move, fuse and divide. Their overall morphology is determined by fusion-fission equilibrium, which depends on the cellular and physiological context. Differentiation is clearly an energy-demending process an increasing body of knowledge has established that mitochondrial dynamics are important for regulating cellular energy metabolism. Therefore, we are studying to what extent mitochondrial fusion and fission dynamics impacts on digestive mesenchymal progenitor differentiation.

 

Legend Figure: MITOTRACKER staining showing the mitochondrial network of digestive Smooth Muscle Cells.


 Collaborations :

  • G. Labesse, et J.F. Guichou (CBS, CNRS/INSERM, Montpellier),
  • JM. Vanderwinden (Université Libre Bruxelles, Belgium),
  • G. Andelfinger (CHU St Justine, Montreal, Canada),
  • F. Joly (Pôle des maladies de l’appareil digestif, Hôpital Beaujon, Paris),
  • F. Chibon (Institut Bergomié, INSERM, Bordeaux),

 

 Financial Supports :

  •  AFM
  • ARC
  • Association des POIC

Coordinator :

 Participants :

 

Delphine SANTO MARTIRE


Major Publications :

Collaboratives Publications :

Patents :

  • De Santa Barbara, P. and Guichou, JF. (2014) « Methods and Pharmaceutical compositions for treatment of Chronic Intestinal PseudoObstruction: CIPO/RBPMS2. » International Patent WO2014122199-A1.
  • De Santa Barbara, P. and Guichou, JF. (2014) « Methods and Pharmaceutical compositions for treatment of Gastrointestinal Stromal Tumors: GISTs/RBPMS2. » International Patent WO2014057045-A1.
  • Montero, JL., Montero, V., Molès, JP., de Santa Barbara, P., Clavel, C. and Jover, B. (2011) « Use of D-mannopyranose derivatives as anti-cancer activity. » International Patent. WO2011058245-A1.
  • Montero, JL., Montero, V., Molès, JP., de Santa Barbara, P., Clavel, C. and Jover, B. (2009) « Use of D-mannopyranose derivatives as activators of angiogenesis. » International Patent WO2009138600-A3.
  • Montero, JL., Montero, V., Molès, JP., de Santa Barbara, P., Clavel, C. and Jover, B. (2009) « Use of D-mannopyranose derivatives as inhibitors of angiogenesis. » International Patent WO2009138601-A3.