With complementary expertise, both at the cellular level that In vivo electrophysiology, pharmacology and functional imaging of cardiac and vascular muscles, we are working to identify new cellular and molecular mechanisms of cardiac and vascular pathophysiology to improve diagnosis and propose new therapeutic options.
Among the tools available in the laboratory, we have access to confocal microscopes, patch clamp systems and microelectrodes, Imaging Systems fluorescence coupled or not the measure of contractility, a high-resolution ultrasound system, telemetry intra-cardiac exploration systems and for recording the electrocardiogram, imaging system and measurement of ex vivo contractility of histology platforms, molecular biology and protein biochemistry. (See More)
Theme 1 : Cardiac conduction disorders and Ventricular Arrhythmias
Theme 1.1 : Autonomic nervous system, circulating factors and calcium homeostasis in arrhythmogenesis
Sudden deaths and deaths « undeserved » from heart diseases are responsible for over one million deaths per year in Europe. The majority of these deaths are due to the occurrence of malignant ventricular arrhythmias that fires after a myocardial infarction, heart failure may progress.Considering that studying the heart in isolation from the rest of the body allows only partial approach of arrhythmogenic mechanisms, we study the role of the autonomic nervous system and circulating factors the functional and structural remodeling of the heart but also the autonomic nervous system. To develop fatal ventricular arrhythmias require 1) a trigger, such as a « disorder » electrophysiological giving birth to a……..(See more)
Theme 1.2 : Role of ion channel TRPM4 in cardiac pathophysiology
Considering that studying the heart in isolation from the rest of the body allows only partial approach of arrhythmogenic mechanisms, we study functional alterations of membrane ion channels and circulating factors the functional and structural remodeling of the heart but also the autonomic nervous system.TRPM4 is nonselective cation channel activated by intracellular calcium whose expression is ubiquitous (immune system, beta cells of the pancreas, brain arteries …). However, at the heart level, its presence is ………… (See more)
Theme 1.3 : Non-enzymatic oxidized metabolites of polyunsaturated fatty acids Omega-3 and normal and pathological muscle function
The cardioprotective role of omega-3 polyunsaturated fatty acids (PUFA ω3) has been known since the 1970s. Progressively, many laboratories have attempted to understand the origin of this cardioprotection which mainly following a myocardial infarction but none consensus made is yet found. In collaboration with chemists IBMM, we hypothesized that these are not the fatty acids themselves are active but the oxidation products of these lipids. ….. (See more)
Theme 2 : Pathophysiology of systemic and pulmonary arterial contraction
Theme 2.1 : Regulation of sodium and calcium homeostasis in the arterial smooth muscle cell.
We have demonstrated a functional role of voltage-gated sodium channels (Nav) in the regulation of blood contraction of………. (See more)
Theme 2.2 : Vascular remodeling in human pulmonary arterial hypertension.
Idiopathic pulmonary arterial hypertension (idiopathic HTAP) is a rare, fatal, which develops in a primitive way. It is identified by…………………………….. (See more)
Theme 3 : Stem cells: diagnostics and mechanistic studies in muscle pathophysiology.
In France, myocardial infarction (IdM) is for 100,000 people and kills 13% of people after 1 year and 70% after 5 years. However, pharmacological treatments already widely explored, only slow…………………………….. (See more)