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 INSERM U1046, CNRS UMR9214, Université de Montpellier.

Director : Jacques MERCIER; Co-Director : Sylvain RICHARD

We develop modern approaches to conduct excellent fundamental research and deduce from theses, new impact in the field of muscle diseases. Our researches in the biomedical field will focus on understanding the molecular basis of various chronic and / or hereditary diseases and then consider possible innovative therapeutic strategies.


Adresse :  371 Avenue du Doyen G. Giraud, CHU Arnaud de Villeneuve, Bâtiment Crastes de Paulet, 34295 Montpellier, Cedex 5, France.

Tel : 04 67 41 52 40;  Fax : 04 67 41 52 42

E.mail : U1046

4 areas of Research are developed within this Unit:

Team 1 – Ion channels and calcium homeostasis in cardiac muscle and vascular muscles

Our research focuses on the identification of novel cellular and molecular mechanisms of cardiac and vascular pathophysiology in order to offer new therapeutic options. We recognized in vivo electrophysiology cell expertise, pharmacology, imaging, study of cellular functions (signaling, contractility, proliferation, apoptosis). Applied to experimental models and tissues obtained from patients, it is part of a dynamic development of translational research. See more

Team 2 – Calcium signaling and function of the sarcomere in cardiac and skeletal muscle

The research team, basic and clinical, is interested in the analysis of signal transduction leading to the contraction of skeletal muscles during conditions such as myocardial ischemia, ventilatory dysfunction and muscular dystrophies. See more

Team 3 – Skeletal muscle dysfunction in acquired and inherited diseases

This team is developing a translational research whose goal is to understand the involvement of skeletal muscle in the pathophysiology of acquired and inherited chronic disease for the development of innovative therapeutic strategies. See more

Team 4 – Development of visceral smooth muscle and associated pathologies.

The main purpose of this research is the identification and understanding of the molecular mechanisms that affect smooth muscles in the digestive chronic diseases (such as motility disorders, disorders of GIST and disorders associated with diabetes). See more

(last Update :April 2018)